Double-strand break repair via break-induced replication

Across TCGA cell cohorts, RNA activity of the Double-strand break repair via break-induced replication pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM136A, MED1, and TRABD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via break-induced replication activity versus FAM136A in LARGE_INTESTINE (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM136A →	+0.694	+0.381	<.001	<.001	3	6
LIVER	MED1 →	+0.725	+0.569	.001	.009	3	5
KIDNEY	TRABD →	+0.816	+0.307	.001	.008	3	5
BREAST	NCAPD3 →	+1.110	+0.315	<.001	.003	3	5
BLOOD_Leukemia	EME1 →	+0.562	+0.116	.002	.007	2	6
OVARY	MCM6 →	+1.418	+0.476	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000727 vs FAM136A — LARGE_INTESTINE

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