Recombinational repair

Across TCGA patient cohorts, RNA activity of the Recombinational repair pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCF20, CEP128, and TTI1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Recombinational repair activity versus TCF20 in DLBC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	TCF20 →	+1.103	+0.061	<.001	<.001	3	34
THYM	CEP128 →	+1.779	+0.043	<.001	<.001	3	34
DLBC	TTI1 →	+1.071	+0.065	<.001	<.001	3	34
UVM	SMCHD1 →	+1.571	+0.032	<.001	<.001	3	34
DLBC	CEP76 →	+1.254	+0.077	<.001	<.001	3	34
UVM	POLA1 →	+1.169	+0.024	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000725 vs TCF20 — DLBC

Explore this scatter interactively →