Recombinational repair

Across TCGA cell cohorts, RNA activity of the Recombinational repair pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LONRF1, STOX1, and TAGLN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LONRF1 grouped by Recombinational repair-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LONRF1 →	-1.123	-0.155	.005	.004	3	5
LARGE_INTESTINE	STOX1 →	-1.302	-0.150	<.001	.002	3	5
LARGE_INTESTINE	TAGLN2 →	+0.746	+0.119	.003	.001	3	4
LARGE_INTESTINE	GBP2 →	+1.301	+0.172	.001	.002	2	5
LARGE_INTESTINE	MYO7B →	+2.398	+0.134	.001	.009	3	4
URINARY_TRACT	NLRP1 →	+2.137	+0.230	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LONRF1 by Recombinational repair activity — LARGE_INTESTINE

Explore this box plot interactively →