Recombinational repair

Across TCGA cell cohorts, RNA activity of the Recombinational repair pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INCENP, USP39, and NUP188, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Recombinational repair activity versus INCENP in BLOOD_Leukemia (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	INCENP →	+0.949	+0.132	.002	<.001	3	7
BLOOD_Leukemia	USP39 →	+0.423	+0.102	.004	.002	3	7
BLOOD_Leukemia	NUP188 →	+0.622	+0.114	.001	<.001	3	6
LUNG_SCLC	PDXP →	+1.169	+0.221	<.001	<.001	3	6
OVARY	SRSF7 →	+0.536	+0.261	<.001	<.001	3	6
LUNG_SCLC	ILF3 →	+0.652	+0.199	.007	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000725 vs INCENP — BLOOD_Leukemia

Explore this scatter interactively →