Telomere maintenance

Across TCGA patient cohorts, RNA activity of the Telomere maintenance pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB36, MCM9, and EPX, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance activity versus RAB36 in COAD (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAB36 →	+1.029	+0.203	<.001	.002	3	1
COAD	MCM9 →	+0.440	+0.153	<.001	.004	3	1
COAD	EPX →	+0.221	+0.208	<.001	.004	3	1
COAD	GCNT7 →	+0.598	+0.149	.001	.004	3	1
COAD	CRYGN →	-0.123	-0.196	<.001	<.001	3	1
COAD	PSME3 →	+0.813	+0.176	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000723 vs RAB36 — COAD

Explore this scatter interactively →