Telomere maintenance

Across TCGA cell cohorts, RNA activity of the Telomere maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SF3B2, MRPL49, and RBM38, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance activity versus SF3B2 in LARGE_INTESTINE (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SF3B2 →	+0.548	+0.119	.001	.008	3	6
LARGE_INTESTINE	MRPL49 →	+0.607	+0.167	<.001	<.001	3	6
BLOOD_Lymphoma	RBM38 →	+1.273	+0.084	<.001	.003	3	6
SOFT_TISSUE	BAZ2A →	+0.801	+0.132	.007	.008	3	5
OVARY	MTMR1 →	+1.031	+0.152	.001	.003	3	5
OVARY	PUSL1 →	+0.664	+0.169	.006	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000723 vs SF3B2 — LARGE_INTESTINE

Explore this scatter interactively →