Embryonic axis specification

Across TCGA patient cohorts, RNA activity of the Embryonic axis specification pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF236, SMARCC2, and ZNF507, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic axis specification activity versus ZNF236 in DLBC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ZNF236 →	+1.321	+0.051	<.001	<.001	3	31
DLBC	SMARCC2 →	+1.922	+0.051	<.001	<.001	3	31
DLBC	ZNF507 →	+0.807	+0.040	<.001	<.001	3	31
DLBC	EP400 →	+0.935	+0.047	<.001	<.001	3	31
DLBC	BOD1L1 →	+1.438	+0.049	<.001	<.001	3	31
DLBC	USP42 →	+0.959	+0.042	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000578 vs ZNF236 — DLBC

Explore this scatter interactively →