Embryonic axis specification

Across TCGA cell cohorts, RNA activity of the Embryonic axis specification pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD5, SATB2, and SMAD6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FZD5 grouped by Embryonic axis specification-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FZD5 →	-0.183	-0.725	<.001	<.001	3	8
LARGE_INTESTINE	SATB2 →	-0.182	-0.267	<.001	.004	3	6
CNS	SMAD6 →	-0.201	-0.765	.009	.003	2	6
KIDNEY	UBE2J1 →	-0.219	-0.919	<.001	.007	3	5
LUNG_NSCLC_LUSC	EID1 →	-0.277	-1.360	.009	.003	2	6
BREAST	PITX3 →	-0.187	-0.816	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FZD5 by Embryonic axis specification activity — CNS

Explore this box plot interactively →