Embryonic axis specification

Across TCGA cell cohorts, RNA activity of the Embryonic axis specification pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, ERBB3, and ZNF236, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by Embryonic axis specification-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TEAD1 →	+0.626	+1.997	.009	<.001	3	6
LARGE_INTESTINE	ERBB3 →	+0.164	+1.209	<.001	<.001	3	5
PANCREAS	ZNF236 →	-0.290	-1.638	<.001	<.001	3	3
LIVER	MFSD4A →	+0.293	+2.022	.004	<.001	3	3
OVARY	ANXA5 →	-0.252	-1.329	.004	.006	3	3
SKIN	SERPINI2 →	-0.090	-0.984	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by Embryonic axis specification activity — LIVER

Explore this box plot interactively →