Embryonic axis specification

Across TCGA cell cohorts, RNA activity of the Embryonic axis specification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, ADTRP, and SERPINB2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic axis specification activity versus BASP1 in LUNG_SCLC (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BASP1 →	+5.257	+1.594	<.001	<.001	3	11
LIVER	ADTRP →	+1.256	+1.515	.002	<.001	3	6
BLOOD_Leukemia	SERPINB2 →	+2.925	+1.120	.002	.006	2	6
LIVER	LMTK2 →	-0.940	-1.920	.001	<.001	3	5
BREAST	SYNPO →	+1.693	+1.108	.001	<.001	3	5
LIVER	MCCC2 →	-0.899	-1.293	.001	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000578 vs BASP1 — LUNG_SCLC

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