Small nucleolar ribonucleoprotein complex assembly

Across TCGA patient cohorts, RNA activity of the Small nucleolar ribonucleoprotein complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADNP, HNRNPH1, and RNASEH2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Small nucleolar ribonucleoprotein complex assembly activity versus ADNP in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADNP →	+0.423	+0.080	<.001	<.001	3	6
LSCC	HNRNPH1 →	+0.184	+0.050	<.001	<.001	3	6
OV	RNASEH2A →	+0.270	+0.030	.001	.009	3	5
BRCA	THRAP3 →	+0.191	+0.023	.001	.001	3	5
OV	GPALPP1 →	+0.478	+0.041	<.001	<.001	3	5
OV	INTS3 →	+0.297	+0.032	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000491 vs ADNP — LSCC

Explore this scatter interactively →