Small nucleolar ribonucleoprotein complex assembly

Across TCGA cell cohorts, RNA activity of the Small nucleolar ribonucleoprotein complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNTA1, EXPH5, and ATP8B2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNTA1 grouped by Small nucleolar ribonucleoprotein complex assembly-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SNTA1 →	+2.844	+0.151	.001	.002	3	5
STOMACH	EXPH5 →	-1.559	-0.110	.007	.001	3	5
STOMACH	ATP8B2 →	+2.710	+0.110	.006	.008	2	6
LUNG_NSCLC_LUSC	B3GALT6 →	+0.934	+0.150	.001	<.001	3	5
LARGE_INTESTINE	BOD1 →	+0.750	+0.099	.002	.007	3	5
LARGE_INTESTINE	SGMS1 →	+0.896	+0.105	.004	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNTA1 by Small nucleolar ribonucleoprotein complex assembly activity — STOMACH

Explore this box plot interactively →