Small nucleolar ribonucleoprotein complex assembly

Across TCGA cell cohorts, RNA activity of the Small nucleolar ribonucleoprotein complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JPH1, RAB3IP, and CCDC120, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Small nucleolar ribonucleoprotein complex assembly activity versus JPH1 in BREAST (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	JPH1 →	+1.259	+0.104	<.001	.002	3	3
BLOOD_Myeloma	RAB3IP →	+1.094	+0.130	.001	.008	3	3
BLOOD_Myeloma	CCDC120 →	+1.956	+0.203	.002	.001	3	3
KIDNEY	FAM120AOS →	+0.937	+0.212	.004	<.001	3	3
BLOOD_Myeloma	ADGRL1 →	-2.015	-0.162	<.001	<.001	3	3
KIDNEY	SNX15 →	+0.936	+0.208	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000491 vs JPH1 — BREAST

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