"Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA patient cohorts, RNA activity of the "Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNHG17, HROB, and NCAPH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" activity versus SNHG17 in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SNHG17 →	+0.397	+0.168	<.001	.007	3	6
UCEC	HROB →	+0.649	+0.142	<.001	.003	3	6
BRCA	NCAPH →	+0.643	+0.170	.001	.004	3	6
UCEC	PLK1 →	+0.920	+0.289	<.001	<.001	3	5
UCEC	CDKN3 →	+0.810	+0.235	<.001	<.001	3	5
UCEC	VRK1 →	+0.758	+0.284	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000480 vs SNHG17 — BRCA

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