Maturation of LSU-rRNA

Across TCGA patient cohorts, RNA activity of the Maturation of LSU-rRNA pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AP1B1, TPX2_S738, and U2AF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maturation of LSU-rRNA activity versus AP1B1 in CCRCC (Pearson r = -0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AP1B1 →	-0.185	-0.032	<.001	<.001	3	7
LUAD	TPX2_S738 →	+0.773	+0.043	<.001	<.001	3	6
HNSC	U2AF2 →	+0.203	+0.078	<.001	.001	3	6
HNSC	SMARCD1 →	+0.326	+0.088	<.001	.003	3	6
HNSC	ZMYM3 →	+0.310	+0.077	<.001	.002	3	6
LUAD	DNAJC2 →	+0.295	+0.046	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000470 vs AP1B1 — CCRCC

Explore this scatter interactively →