Maturation of LSU-rRNA

Across TCGA patient cohorts, RNA activity of the Maturation of LSU-rRNA pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZWINT, CCNB2, and CDCA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maturation of LSU-rRNA activity versus ZWINT in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZWINT →	+0.911	+0.397	<.001	<.001	3	8
BRCA	CCNB2 →	+0.894	+0.290	<.001	<.001	3	8
BRCA	CDCA2 →	+0.937	+0.300	<.001	<.001	3	8
BRCA	FAM198B-AS1 →	-1.010	-0.326	<.001	<.001	3	8
LUAD	TRIP13 →	+0.979	+0.259	<.001	<.001	3	8
LUAD	PARPBP →	+0.834	+0.374	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000470 vs ZWINT — BRCA

Explore this scatter interactively →