Maturation of LSU-rRNA

Across TCGA cell cohorts, RNA activity of the Maturation of LSU-rRNA pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUMO2, ZBTB7A, and FBRS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maturation of LSU-rRNA activity versus SUMO2 in OESOPHAGUS (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SUMO2 →	-0.638	-0.270	.007	<.001	3	6
CNS	ZBTB7A →	-0.442	-0.215	.009	.002	3	6
BREAST	FBRS →	-0.616	-0.218	<.001	.001	3	6
LARGE_INTESTINE	SCP2 →	-0.781	-0.222	.007	<.001	3	6
BLOOD_Leukemia	GNG2 →	-2.534	-0.144	.001	.003	3	6
BLOOD_Leukemia	NAP1L4 →	-0.469	-0.103	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000470 vs SUMO2 — OESOPHAGUS

Explore this scatter interactively →