"Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA patient cohorts, RNA activity of the "Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNHIT6, RRP1B, and STIM1_S257, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" activity versus ZNHIT6 in LSCC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNHIT6 →	+0.366	+0.050	<.001	<.001	3	8
LSCC	RRP1B →	+0.351	+0.060	<.001	<.001	3	6
UCEC	STIM1_S257 →	-0.501	-0.076	.005	<.001	2	7
LSCC	ELAVL1_S202 →	+0.615	+0.061	<.001	<.001	3	6
LSCC	MCM2_S139 →	+0.764	+0.081	<.001	<.001	3	6
LSCC	REXO4 →	+0.513	+0.070	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000463 vs ZNHIT6 — LSCC

Explore this scatter interactively →