"Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA patient cohorts, RNA activity of the "Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AUNIP, CDCA5, and CDC25C, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" activity versus AUNIP in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AUNIP →	+0.873	+0.227	<.001	<.001	3	7
BRCA	CDCA5 →	+1.151	+0.388	<.001	<.001	3	7
CCRCC	CDC25C →	+0.724	+0.338	<.001	<.001	3	7
LUAD	CDC6 →	+1.027	+0.262	<.001	<.001	3	7
BRCA	CCNB2 →	+1.084	+0.351	<.001	<.001	3	7
BRCA	RAD51 →	+0.699	+0.302	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000463 vs AUNIP — HNSC

Explore this scatter interactively →