"Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA cell cohorts, RNA activity of the "Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMPD3, TLE5, and NNT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" activity versus SMPD3 in BLOOD_Leukemia (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SMPD3 →	-2.340	-0.152	.006	.004	3	6
BLOOD_Leukemia	TLE5 →	-1.265	-0.153	.003	.004	3	6
LUNG_SCLC	NNT →	-1.607	-0.266	.001	.001	3	6
LUNG_SCLC	OAZ1 →	-0.538	-0.211	<.001	.003	3	6
LUNG_SCLC	KDM4B →	-0.955	-0.291	.002	.008	3	6
LUNG_SCLC	SCOC →	-1.053	-0.257	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000463 vs SMPD3 — BLOOD_Leukemia

Explore this scatter interactively →