"Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA patient cohorts, RNA activity of the "Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSE1L, CENPH, and MEF2C, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" activity versus CSE1L in UCEC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CSE1L →	+0.698	+0.224	<.001	<.001	3	8
HNSC	CENPH →	+0.788	+0.146	.002	.002	3	8
HNSC	MEF2C →	-0.987	-0.197	<.001	<.001	3	8
LUAD	C6 →	-0.813	-0.216	<.001	<.001	3	8
UCEC	FAM83D →	+1.358	+0.250	<.001	<.001	3	7
LUAD	FOXM1 →	+1.218	+0.276	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000462 vs CSE1L — UCEC

Explore this scatter interactively →