Pexophagy

Across TCGA patient cohorts, RNA activity of the Pexophagy pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP30, TRMT13, and RICTOR, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pexophagy activity versus USP30 in ACC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	USP30 →	+0.740	+0.038	.001	.007	1	29
UVM	TRMT13 →	+0.825	+0.033	<.001	<.001	3	26
UVM	RICTOR →	+0.824	+0.036	<.001	<.001	3	26
THYM	ANKRA2 →	+1.035	+0.040	<.001	<.001	3	26
THYM	THAP9 →	+0.755	+0.042	<.001	<.001	3	26
UVM	PCMTD1 →	+1.323	+0.033	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000425 vs USP30 — ACC

Explore this scatter interactively →