Pexophagy

Across TCGA patient cohorts, RNA activity of the Pexophagy pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGEF1, USP5, and CMAS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pexophagy activity versus ARHGEF1 in GBM (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGEF1 →	-0.244	-0.048	<.001	<.001	3	7
LUAD	USP5 →	+0.201	+0.050	.003	<.001	3	6
CCRCC	CMAS →	+0.206	+0.041	<.001	<.001	3	6
COAD	RRM2 →	-0.350	-0.024	<.001	<.001	3	5
GBM	FLII →	-0.186	-0.043	<.001	.001	3	5
COAD	MAGED2 →	+0.319	+0.043	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000425 vs ARHGEF1 — GBM

Explore this scatter interactively →