Pexophagy

Across TCGA patient cohorts, RNA activity of the Pexophagy pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQSTM1, DNASE2, and FZD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pexophagy activity versus SQSTM1 in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SQSTM1 →	+0.729	+0.658	<.001	<.001	3	4
LSCC	DNASE2 →	+0.392	+0.616	.005	.002	3	4
OV	FZD3 →	-0.714	-0.209	.008	.001	3	4
UCEC	LRP2BP →	-0.535	-0.444	<.001	.001	3	4
CCRCC	BCL2L12P1 →	+0.196	+0.651	.005	.001	3	4
UCEC	STAC →	+0.599	+0.670	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000425 vs SQSTM1 — LSCC

Explore this scatter interactively →