Mitophagy

Across TCGA patient cohorts, RNA activity of the Mitophagy pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL4A2-AS1, NCEH1, and LINC02207, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitophagy activity versus COL4A2-AS1 in CCRCC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COL4A2-AS1 →	-0.526	-0.872	.006	<.001	2	5
LSCC	NCEH1 →	+0.671	+0.436	.003	.008	3	3
LUAD	LINC02207 →	-0.204	-0.241	.005	.009	3	3
OV	ZNF77 →	-0.393	-0.598	.001	.002	3	3
CCRCC	MIR99AHG →	-0.489	-0.865	.001	<.001	3	3
OV	TPTEP2 →	-0.479	-0.591	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000423 vs COL4A2-AS1 — CCRCC

Explore this scatter interactively →