Mitophagy

Across TCGA cell cohorts, RNA activity of the Mitophagy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R35, LBHD1, and ACSS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R35 grouped by Mitophagy-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PPP1R35 →	-1.019	-0.389	.006	.008	3	5
CNS	LBHD1 →	+0.616	+0.198	.003	.006	3	4
SOFT_TISSUE	ACSS1 →	+3.114	+0.258	<.001	.003	3	4
OESOPHAGUS	GPR146 →	-0.780	-0.130	.006	.002	3	3
OESOPHAGUS	NSG1 →	-1.872	-0.156	.002	.004	3	3
BREAST	RGPD5 →	+1.144	+0.174	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R35 by Mitophagy activity — BLOOD_Lymphoma

Explore this box plot interactively →