Mitophagy

Across TCGA cell cohorts, RNA activity of the Mitophagy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are URGCP, SPCS3, and FGD6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitophagy activity versus URGCP in BLOOD_Myeloma (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	URGCP →	+0.845	+0.114	.006	.001	3	4
BLOOD_Myeloma	SPCS3 →	-1.105	-0.095	.009	<.001	3	4
BLOOD_Myeloma	FGD6 →	+0.906	+0.106	.005	.003	3	4
OVARY	CSNK1G2 →	-0.591	-0.189	.001	.002	3	4
LIVER	MT-ND3 →	+0.878	+0.302	.007	.007	3	4
KIDNEY	TRIM47 →	+1.050	+0.228	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000423 vs URGCP — BLOOD_Myeloma

Explore this scatter interactively →