Mitophagy

Across TCGA cell cohorts, RNA activity of the Mitophagy pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHB2, PFDN5, and NIPSNAP2, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitophagy activity versus PHB2 in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PHB2 →	+0.783	+0.237	<.001	<.001	3	13
OVARY	PFDN5 →	-1.725	-0.295	<.001	.001	3	11
BREAST	NIPSNAP2 →	+0.930	+0.181	<.001	<.001	3	11
LUNG_NSCLC_LUAD	NASP →	-0.873	-0.160	.009	.004	3	10
STOMACH	EDF1 →	-1.347	-0.268	.003	<.001	3	10
OVARY	VBP1 →	-1.707	-0.299	<.001	.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000423 vs PHB2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →