Autophagy of mitochondrion

Across TCGA patient cohorts, RNA activity of the Autophagy of mitochondrion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S432, PPP1R12B, and SEPTIN4_S117, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagy of mitochondrion activity versus SEPTIN4_S432 in GBM (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4_S432 →	+0.702	+0.037	<.001	<.001	3	7
CCRCC	PPP1R12B →	+0.646	+0.038	.002	<.001	3	5
BRCA	SEPTIN4_S117 →	+0.688	+0.030	<.001	.002	3	5
PDAC	SORBS2 →	+0.305	+0.023	.004	.007	3	5
GBM	SRCIN1_S987 →	+0.870	+0.057	<.001	<.001	3	5
PDAC	TCEAL1 →	+0.303	+0.031	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000422 vs SEPTIN4_S432 — GBM

Explore this scatter interactively →