Autophagy of mitochondrion

Across TCGA cell cohorts, RNA activity of the Autophagy of mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTBD2, LNX1, and RPS4X, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagy of mitochondrion activity versus BTBD2 in BONE (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BTBD2 →	-1.820	-0.229	.001	.008	3	5
BONE	LNX1 →	+1.827	+0.292	<.001	.007	3	5
PANCREAS	RPS4X →	-0.908	-0.226	.003	.005	3	5
BLOOD_Lymphoma	EEF1G →	-0.811	-0.207	.002	.002	3	5
LIVER	HDHD5 →	-0.914	-0.263	.002	.001	3	5
SKIN	RAB9A →	-0.655	-0.189	.004	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000422 vs BTBD2 — BONE

Explore this scatter interactively →