Protein peptidyl-prolyl isomerization

Across TCGA patient cohorts, RNA activity of the Protein peptidyl-prolyl isomerization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPIC, TOE1, and FLNB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein peptidyl-prolyl isomerization activity versus PPIC in CCRCC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PPIC →	+0.707	+0.047	<.001	<.001	3	5
LSCC	TOE1 →	+0.218	+0.035	<.001	<.001	3	4
CCRCC	FLNB →	-0.364	-0.063	.003	<.001	3	4
COAD	FAM83G_S650 →	-0.219	-0.026	.004	.003	3	4
LUAD	OPLAH →	-0.289	-0.039	.003	.001	3	4
HNSC	PRRC2A →	+0.182	+0.068	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000413 vs PPIC — CCRCC

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