Protein peptidyl-prolyl isomerization

Across TCGA patient cohorts, RNA activity of the Protein peptidyl-prolyl isomerization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, SPC24, and KIFC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein peptidyl-prolyl isomerization activity versus GINS1 in BRCA (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GINS1 →	+0.520	+0.132	.007	.009	3	6
OV	SPC24 →	+0.696	+0.161	.005	.003	3	5
OV	KIFC1 →	+1.045	+0.153	<.001	.007	3	5
OV	SPAG5 →	+0.729	+0.162	<.001	.002	3	5
OV	AURKA →	+0.738	+0.148	.001	.005	3	5
OV	CDC6 →	+0.586	+0.172	.003	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000413 vs GINS1 — BRCA

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