Protein peptidyl-prolyl isomerization

Across TCGA cell cohorts, RNA activity of the Protein peptidyl-prolyl isomerization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELAPOR2, PSG9, and MPLKIP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELAPOR2 grouped by Protein peptidyl-prolyl isomerization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ELAPOR2 →	+1.948	+1.436	.006	.001	3	3
SKIN	PSG9 →	-0.345	-0.818	.002	.009	3	3
LARGE_INTESTINE	MPLKIP →	-0.553	-1.488	.002	<.001	3	3
KIDNEY	FGF11 →	-1.663	-1.200	.009	.002	3	3
LUNG_NSCLC_LUSC	DSE →	-1.645	-1.363	<.001	<.001	3	3
LUNG_NSCLC_LUSC	TRIM21 →	-1.349	-1.799	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELAPOR2 by Protein peptidyl-prolyl isomerization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →