Protein peptidyl-prolyl isomerization

Across TCGA cell cohorts, RNA activity of the Protein peptidyl-prolyl isomerization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHDC3, ARHGEF37, and KCTD20, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein peptidyl-prolyl isomerization activity versus KLHDC3 in BREAST (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KLHDC3 →	+0.579	+0.103	.007	.002	3	5
SKIN	ARHGEF37 →	-1.241	-0.170	.004	.003	3	5
OVARY	KCTD20 →	+0.792	+0.167	.002	.004	3	5
OVARY	TMEM265 →	-2.358	-0.177	.008	.002	3	5
BLOOD_Lymphoma	SBK1 →	+0.627	+0.117	.005	<.001	3	5
BONE	HNRNPA1 →	+1.024	+0.317	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000413 vs KLHDC3 — BREAST

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