RNA 5'-splice site recognition

Across TCGA patient cohorts, RNA activity of the RNA 5'-splice site recognition pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NTHL1_S71, AHNAK_S3416, and ALMS1_S189, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA 5'-splice site recognition activity versus NTHL1_S71 in BRCA (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NTHL1_S71 →	+1.115	+0.066	<.001	.004	3	5
PDAC	AHNAK_S3416 →	-0.547	-0.062	.005	.002	3	4
CCRCC	ALMS1_S189 →	-0.195	-0.045	<.001	.003	3	4
CCRCC	MAP7D1_S254 →	-0.420	-0.053	.007	.006	3	4
GBM	AHNAK2_S1418 →	-0.855	-0.044	.001	.009	3	4
LSCC	S100A9 →	-1.160	-0.064	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000395 vs NTHL1_S71 — BRCA

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