RNA 5'-splice site recognition

Across TCGA patient cohorts, RNA activity of the RNA 5'-splice site recognition pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXO3B, MUTYH, and ARL6IP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA 5'-splice site recognition activity versus FOXO3B in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3B →	+0.452	+0.221	.002	.001	3	5
GBM	MUTYH →	+0.358	+0.477	<.001	<.001	3	5
OV	ARL6IP4 →	+0.212	+0.192	.004	.003	3	5
OV	H1-10-AS1 →	+0.655	+0.227	.006	.002	3	5
GBM	HASPIN →	+0.559	+0.417	<.001	<.001	3	5
GBM	DEFB108B →	+0.498	+0.401	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000395 vs FOXO3B — UCEC

Explore this scatter interactively →