RNA 5'-splice site recognition

Across TCGA cell cohorts, RNA activity of the RNA 5'-splice site recognition pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LENG9, ZYX, and ARHGAP17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LENG9 grouped by RNA 5'-splice site recognition-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	LENG9 →	+1.396	+0.274	.005	.004	3	4
LUNG_SCLC	ZYX →	-3.541	-0.320	<.001	.004	3	4
LIVER	ARHGAP17 →	-0.643	-0.201	.005	.006	3	4
LIVER	TRAM2 →	-1.847	-0.300	.001	.002	3	4
PANCREAS	NUP214 →	+1.057	+0.176	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	SERTAD4 →	-1.293	-0.143	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LENG9 by RNA 5'-splice site recognition activity — LIVER

Explore this box plot interactively →