RNA 5'-splice site recognition

Across TCGA cell cohorts, RNA activity of the RNA 5'-splice site recognition pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCKAP1, SLC20A1, and ADAM29, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NCKAP1 grouped by RNA 5'-splice site recognition-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NCKAP1 →	+0.234	+0.109	.003	<.001	3	4
BLOOD_Leukemia	SLC20A1 →	+0.193	+0.097	<.001	<.001	3	4
KIDNEY	ADAM29 →	-0.157	-0.121	.006	.004	3	4
PANCREAS	RPTN →	+0.330	+0.127	.009	.006	3	4
SKIN	PDIA5 →	-0.258	-0.127	<.001	<.001	3	4
SOFT_TISSUE	MUCL3 →	+0.179	+0.109	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NCKAP1 by RNA 5'-splice site recognition activity — BREAST

Explore this box plot interactively →