"RNA splicing, via endonucleolytic cleavage and ligation"

Across TCGA patient cohorts, RNA activity of the "RNA splicing, via endonucleolytic cleavage and ligation" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HCFC1, PLXNB2, and RPRD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "RNA splicing, via endonucleolytic cleavage and ligation" activity versus HCFC1 in LSCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HCFC1 →	+0.199	+0.060	<.001	<.001	3	7
GBM	PLXNB2 →	-0.260	-0.041	<.001	<.001	3	7
LSCC	RPRD2 →	+0.270	+0.056	<.001	<.001	3	7
UCEC	PARP1 →	+0.300	+0.070	<.001	<.001	3	7
LSCC	GATAD2B →	+0.324	+0.055	<.001	<.001	3	7
LSCC	ADNP →	+0.339	+0.048	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000394 vs HCFC1 — LSCC

Explore this scatter interactively →