"RNA splicing, via endonucleolytic cleavage and ligation"

Across TCGA patient cohorts, RNA activity of the "RNA splicing, via endonucleolytic cleavage and ligation" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND3, THEMIS2, and RASGRP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "RNA splicing, via endonucleolytic cleavage and ligation" activity versus DENND3 in GBM (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DENND3 →	-0.659	-0.106	<.001	.007	3	6
LSCC	THEMIS2 →	-0.691	-0.246	<.001	<.001	3	5
LSCC	RASGRP4 →	-0.334	-0.179	.006	.003	3	5
LSCC	CLEC1A →	-0.662	-0.201	<.001	<.001	3	5
LSCC	NCF4 →	-0.873	-0.244	<.001	<.001	3	4
LSCC	BIN2 →	-0.691	-0.212	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000394 vs DENND3 — GBM

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