"RNA splicing, via endonucleolytic cleavage and ligation"

Across TCGA cell cohorts, RNA activity of the "RNA splicing, via endonucleolytic cleavage and ligation" pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUMB, TBC1D8B, and PPM1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "RNA splicing, via endonucleolytic cleavage and ligation" activity versus NUMB in SOFT_TISSUE (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NUMB →	+1.145	+0.262	.001	.002	3	5
SOFT_TISSUE	TBC1D8B →	+1.914	+0.296	.002	.001	3	4
STOMACH	PPM1A →	+0.941	+0.235	.001	.003	2	5
CNS	CLEC4A →	+0.398	+0.219	.003	<.001	3	4
CNS	SLC39A9 →	+0.541	+0.159	.001	.005	3	4
CNS	AP5M1 →	+0.832	+0.204	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000394 vs NUMB — SOFT_TISSUE

Explore this scatter interactively →