Spliceosomal conformational changes to generate catalytic conformation

Across TCGA patient cohorts, RNA activity of the Spliceosomal conformational changes to generate catalytic conformation pathway is significantly associated with the RNA expression of multiple genes, with the LIHC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISY1, RNF7, and RBM17, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spliceosomal conformational changes to generate catalytic conformation activity versus ISY1 in LIHC (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	ISY1 →	+0.736	+0.054	<.001	<.001	3	29
ACC	RNF7 →	+1.066	+0.050	<.001	<.001	3	28
ACC	RBM17 →	+1.142	+0.051	<.001	<.001	3	28
UVM	CCDC58 →	+1.139	+0.035	<.001	<.001	3	27
UVM	KIN →	+1.055	+0.034	<.001	<.001	3	27
ACC	RPP38 →	+0.628	+0.038	.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000393 vs ISY1 — LIHC

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