Spliceosomal conformational changes to generate catalytic conformation

Across TCGA patient cohorts, RNA activity of the Spliceosomal conformational changes to generate catalytic conformation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS26P42, MIRLET7G, and MYO1H, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spliceosomal conformational changes to generate catalytic conformation activity versus RPS26P42 in COAD (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS26P42 →	-0.102	-0.240	.003	.002	3	5
CCRCC	MIRLET7G →	-1.097	-0.716	.001	<.001	3	4
LSCC	MYO1H →	-0.270	-0.453	.001	.001	3	3
LSCC	QRFP →	-0.352	-0.292	.005	.003	3	3
HNSC	SGK1 →	+0.740	+0.231	<.001	<.001	3	3
CCRCC	ZFP36 →	+0.967	+0.447	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000393 vs RPS26P42 — COAD

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