Spliceosomal conformational changes to generate catalytic conformation

Across TCGA cell cohorts, RNA activity of the Spliceosomal conformational changes to generate catalytic conformation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FSTL3, PCBP4, and IL6ST, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FSTL3 grouped by Spliceosomal conformational changes to generate catalytic conformation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FSTL3 →	+1.233	+0.165	.003	.009	3	6
SOFT_TISSUE	PCBP4 →	+1.284	+0.234	.001	.005	3	5
BREAST	IL6ST →	+1.407	+0.123	.004	.003	3	4
BREAST	DOCK10 →	+1.904	+0.141	.001	.002	3	4
BREAST	ANKRD44 →	+0.655	+0.147	.009	.001	3	4
LUNG_NSCLC_LUSC	SH3KBP1 →	+2.891	+0.181	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FSTL3 by Spliceosomal conformational changes to generate catalytic conformation activity — BLOOD_Leukemia

Explore this box plot interactively →