Spliceosomal conformational changes to generate catalytic conformation

Across TCGA cell cohorts, RNA activity of the Spliceosomal conformational changes to generate catalytic conformation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XAB2, PRPF3, and WDR83, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spliceosomal conformational changes to generate catalytic conformation activity versus XAB2 in LUNG_NSCLC_LUSC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	XAB2 →	+0.754	+0.097	.003	<.001	3	19
BONE	PRPF3 →	+0.898	+0.088	.004	.005	3	15
BREAST	WDR83 →	+0.686	+0.070	<.001	<.001	3	14
URINARY_TRACT	SART1 →	+0.942	+0.101	.009	<.001	3	14
OESOPHAGUS	DPF1 →	+1.308	+0.090	<.001	<.001	3	14
BONE	NUP214 →	+0.736	+0.082	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000393 vs XAB2 — LUNG_NSCLC_LUSC

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