Spliceosomal conformational changes to generate catalytic conformation

Across TCGA cell cohorts, RNA activity of the Spliceosomal conformational changes to generate catalytic conformation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNASE4, MCEE, and ACVR2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spliceosomal conformational changes to generate catalytic conformation activity versus RNASE4 in OVARY (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RNASE4 →	-1.628	-0.224	<.001	<.001	3	7
LARGE_INTESTINE	MCEE →	-0.679	-0.150	.001	<.001	3	6
BREAST	ACVR2B →	+0.483	+0.134	<.001	.001	3	5
BREAST	NASP →	+0.963	+0.165	<.001	.002	3	5
BLOOD_Lymphoma	BCAR3 →	-1.659	-0.133	.007	<.001	3	5
BREAST	ANKRD13B →	+1.081	+0.133	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000393 vs RNASE4 — OVARY

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