Response to oxygen radical

Across TCGA patient cohorts, RNA activity of the Response to oxygen radical pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN5, FBLN5, and ELN, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to oxygen radical activity versus CLDN5 in MESO (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	CLDN5 →	+1.325	+0.024	<.001	.001	3	23
PCPG	FBLN5 →	+1.428	+0.042	<.001	<.001	3	23
ESCA	ELN →	+1.847	+0.058	<.001	<.001	3	23
TGCT	NOS3 →	+0.971	+0.046	<.001	<.001	3	22
CHOL	H19 →	+3.694	+0.046	<.001	.001	2	23
ACC	INMT →	+1.110	+0.033	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000305 vs CLDN5 — MESO

Explore this scatter interactively →