Response to oxygen radical

Across TCGA patient cohorts, RNA activity of the Response to oxygen radical pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ABI3BP, PRPH, and ADH1B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to oxygen radical activity versus ABI3BP in BRCA (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ABI3BP →	+0.852	+0.027	<.001	<.001	3	8
GBM	PRPH →	+0.825	+0.048	<.001	<.001	3	8
OV	ADH1B →	+1.274	+0.031	.001	.002	3	8
CCRCC	TNXB →	+0.777	+0.060	<.001	<.001	3	7
PDAC	CALD1_S202 →	+1.042	+0.050	<.001	.001	3	7
OV	AKAP12_S1512 →	+1.179	+0.044	.003	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000305 vs ABI3BP — BRCA

Explore this scatter interactively →