Response to oxygen radical

Across TCGA patient cohorts, RNA activity of the Response to oxygen radical pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNE4, EIPR1, and RAB5B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to oxygen radical activity versus KCNE4 in GBM (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KCNE4 →	+1.122	+0.143	<.001	<.001	3	5
LSCC	EIPR1 →	-0.405	-0.154	<.001	.001	3	5
OV	RAB5B →	-0.449	-0.172	<.001	<.001	3	4
LSCC	TMEM106B →	-0.432	-0.181	.002	<.001	3	4
LSCC	NPEPPS →	-0.364	-0.155	<.001	<.001	3	4
LSCC	KDM1B →	-0.354	-0.103	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000305 vs KCNE4 — GBM

Explore this scatter interactively →