Response to oxygen radical

Across TCGA cell cohorts, RNA activity of the Response to oxygen radical pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDX1, DOC2B, and PRDX2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to oxygen radical activity versus PRDX1 in BLOOD_Lymphoma (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRDX1 →	+1.149	+0.108	.004	.002	3	8
LUNG_NSCLC_LUSC	DOC2B →	+1.832	+0.369	.008	.004	3	5
LARGE_INTESTINE	PRDX2 →	+0.806	+0.194	.001	.005	3	5
LUNG_SCLC	ABCB6 →	+0.781	+0.119	<.001	.001	3	5
OESOPHAGUS	ZBTB41 →	+0.563	+0.135	.005	.006	3	4
BLOOD_Myeloma	LSM4 →	+0.640	+0.155	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000305 vs PRDX1 — BLOOD_Lymphoma

Explore this scatter interactively →